Deborah Rush has worked in television, film and on Broadway. In 1984, she was nominated for a Tony Award for Best Performance by a Featured Actress in a Play for Michael Frayn's comedy Noises Off. She also acted in Stephen Adly Guirgis' The Last Days of Judas Iscariot. In 2003 she acted in the comedy film American Wedding. In 2008 she joined the cast of the Broadway revival of Blithe Spirit.
Rush has acted in a number of movies and television series, including the Woody Allen films Zelig and The Purple Rose of Cairo. She was a regular cast member of the television series Strangers with Candy. She had a recurring role on Spin City as Helen Winston, eventual ex-wife of mayor Randall Winston, and on Orange Is the New Black, as Piper's mother.