Tiny Grimes began his musical career playing drums and piano. In 1938 he took up the guitar choosing the unusual electric 4-string tenor guitar.
In 1940 he joined the Cats And A Fiddle as guitarist and singer. In 1943 he joined the Art Tatum Trio as guitarist and made a number of recordings with Tatum. The early Tatum Trio recordings made for the Asch and Comet recording labels are some of the more interesting early examples of Tiny Grimes’ guitar work.